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" Mak cik tak nak kaki mak cik kena potong..bukannya senang dik..nak dapat kaki ni" Makcik Muniati shook her head
We all stared at her in disbelief..Her left leg was already necrotic, most of the muscles were devitalized. The stench of the odor from her leg was filling the whole ward.
" Makcik..makcik sayang nyawa ke, atau sayang kaki lebih? makcik boleh mati kalau biarkan macam ni." Mister Jacob was stern this time
" Apa ni doktor..nak paksa-paksa saya pulak!" She scoffed
My specialist was exasperated. The wound was open for her to see. Even with the extensive
wound that we did, and the muscles, bones and the internal structure being open, she was still adamant on keeping the lower limb..
Purpose of wound debridement:
An open wound or ulcer can not be properly evaluated until the dead tissue or foreign matter is removed. Wounds that contain necrotic and ischemic (low oxygen content) tissue take longer to close and heal. This is because necrotic tissue provides an ideal growth medium for bacteria, especially for Bacteroides spp. and Clostridium perfringens that causes the gas gangrene so feared in military medical practice. Though a wound may not necessarily be infected, the bacteria can cause inflammation and strain the body's ability to fight infection. Debridement is also used to treat pockets of pus called abscesses. Abscesses can develop into a general infection that may invade the bloodstream (sepsis) and lead to amputation and even death
NECROTIZING FASCIITIS
necrotizing fascitits is any necrotizing soft tissue infection spreading along fascial planes, with or without overlying cellulitis; - also called Meleney ulcer, NF is severe manifestation of lymphangitis that progresses in a frightening manner within a few hours; - tissue necrosis develops rapidly behind advancing wall of inflammation that limits penetration by antibiotics;
Cardiopulmonary resuscitation (CPR) is an emergency medical procedure for a victim of cardiac arrest or, in some circumstances, respiratory arrest.[1] CPR is performed in hospitals, or in the community by laypersons or by emergency response professionals.[2]
For 50 years CPR has consisted of the combination of artificial blood circulation with artificial respiration[1] i.e., chest compressions and lung ventilation.[3] However, in March 2008 the American Heart Association and the European Resuscitation Council, in a reversal of policy, endorsed the effectiveness of chest compressions alone--without artificial respiration--for adult victims who collapse suddenly in cardiac arrest (see Cardiocerebral Resuscitation below).[4][5] CPR is generally continued, usually in the presence of advanced life support (such as from a medical team or paramedics), until the patient regains a heart beat (called "return of spontaneous circulation" or "ROSC") or is declared dead.
CPR is unlikely to restart the heart, but rather its purpose is to maintain a flow of oxygenated blood to the brain and the heart, thereby delaying tissue death and extending the brief window of opportunity for a successful resuscitation without permanent brain damage.In short, the procedure for "hands-only" CPR is simple. An untrained bystander who sees an adult suddenly collapse (after verifying that the person is unresponsive and is not breathing) should do just two things:
1) Call 911 (or send someone else to do this if you are not alone), and if others are present, send someone to find an AED (automated external defibrillator).
and
2) Push hard and fast in the center of the chest. The rate should be fast, about 100 presses per minute, but it's not necessary to count. Just initiate deep, rapid, continuous presses on the center of the chest and continue until the victim awakens, an AED is found, or emergency personnel arrive.
Hands-only CPR eliminates the mouth-to-mouth breathing of conventional CPR (alternating 30 chest presses and two quick breaths). Although hands-only CPR is very effective, it is not as beneficial as conventional CPR in a patient who is not breathing.
In all children, and in adults who collapse after a near-drowning, drug overdose, or carbon monoxide poisoning, mouth-to-mouth breathing should still be included to get air into the lungs.
Studies have shown that hands-only CPR can be as effective as conventional CPR and may save lives. Those who have been trained in conventional CPR may still opt to use conventional CPR instead of the hands-only technique.
Enoxaparin is a low molecular weight heparin marketed as Lovenox or Clexane. It is used to prevent and treat deep vein thrombosis or pulmonary embolism, and is given as a subcutaneous injection (by a health care provider or the patient). Its use is evolving in acute coronary syndromes (ACS).
Enoxaparin is manufactured by Sanofi-Aventis and is derived from the intestinal mucosa of pigs.
Enoxaparin binds to and accelerates the activity of antithrombin III. By activating antithrombin III, enoxaparin preferentially potentiates the inhibition of coagulation factors Xa and IIa. The anticoagulant effect of enoxaparin can be directly correlated to its ability to inhibit factor Xa. Factor Xa catalyzes the conversion of prothrombin to thrombin, so enoxaparin’s inhibition of this process results in decreased thrombin and ultimately the prevention of fibrin clot formation.Heparin binds to the enzyme inhibitor antithrombin (AT) causing a conformational change that results in its activation through an increase in the flexibility of its reactive site loop.[15] The activated AT then inactivates thrombin and other proteases involved in blood clotting, most notably factor Xa. The rate of inactivation of these proteases by AT can increase by up to 1000-fold due to the binding of heparin.[16]